Key Safety Assessments & Research Studies on BPA

Hundreds of laboratory studies on BPA have been conducted to better understand exposure and potential health effects. While the key BPA research studies summarized here are not intended to be exhaustive, these studies are significant because of their high utility for assessing the safety of BPA. Use the filters below to sort studies by topic focus or enter a specific search term.

  • exposure
    Dietary Exposure – Food Packaging and Bisphenol A and Bis (2-Ethyhexyl) Phthalate Exposure: Findings from a Dietary Intervention
    Date: March 30, 2011 | Authors: Rudel et al. | Publication: Environmental Health Perspectives

    “BPA levels were more than 1,000 times below the government-established safe intake level.”

  • health
    Comparison of lifestage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague-Dawley rats
    Date: January 2, 2014 | Authors: Churchwell et al | Publication: Publication

    “The Churchwell study allows the Delclos results, in their entirety at low and high doses, to be more reliably interpreted…”

  • health
    New FDA study finds no evidence of adverse health effects arising from low dose exposure to BPA
    Date: February 4, 2014 | Authors: Delclos et al. | Publication: Toxicological Sciences

    “Results demonstrated that no low dose effects were found for BPA in the wide range of health endpoints examined.”

  • exposure
    Dietary Exposure – Daily Intake of Bisphenol A (BPA) and Potential Sources of Exposure – 2005-2006 National Health and Nutrition Examination Survey (NHANES)
    Date: March 17, 2010 | Authors: LaKind and Naiman | Publication: Journal of Exposure Science & Environmental Epidemiology

    “These levels are still almost 1,000 times below recommended safe exposure limits…”

  • metabolism
    Metabolism in Monkeys – Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
    Date: October 1, 2010 | Authors: Doerge et al. | Publication: Toxicology and Applied Pharmacology

    “Any toxicological effect observed in rats from early postnatal exposures to BPA could over-predict those possible in primates of the same age…”

  • metabolism
    Metabolism in Rats – Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
    Date: September 1, 2010 | Authors: Doerge et al. | Publication: Toxicology and Applied Pharmacology

    “Studies that expose animals by subcutaneous injection are of limited relevance to human health concerns that primarily involve oral exposure…”

  • exposure metabolism
    Metabolism in Humans – 24-Hour Human Urine and Serum Profiles of Bisphenol A During High Dietary Exposure
    Date: June 24, 2011 | Authors: Teeguarden et al. (2011) | Publication: Toxicological Sciences

    “This study confirmed that BPA is efficiently converted to a biologically inactive metabolite and rapidly excreted…”

  • exposure
    Reproductive Health – Two-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD-1 (Swiss) Mice
    Date: April 15, 2008 | Authors: Rochelle W. Tyl | Publication: Reproductive and Developmental Health

    “BPA is not considered a selective reproductive or developmental toxicant…”

  • health
    Reproductive Health – Basic Exploratory Research versus Guideline-Compliant Studies Used for Hazard Evaluation and Risk Assessment: Bisphenol A as a Case Study
    Date: June 29, 2009 | Authors: Rochelle W. Tyl | Publication: Reproductive and Developmental Health

    “Weight-of-evidence evaluations have consistently concluded that low-level BPA oral exposures do not adversely affect human developmental or reproductive health…”

  • exposure
    Reproductive Behavior – In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats
    Date: October 15, 2009 | Authors: Bryce Ryan | Publication: Reproductive Development and Behavior

    “No effects from exposure to BPA were found in this study.”

  • health
    Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats
    Date: January 22, 2010 | Authors: Donald Stump | Publication: Toxicological Sciences

    “The study concluded that there were no neurologic or neurobehavioral effects at any dose tested.”

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