Metabolism in Rats – Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats

Author: Doerge et al.
Publication: Toxicology and Applied Pharmacology
Date: September 1, 2010

This study concluded that BPA is efficiently metabolized by adult rats after oral exposure and, while neonatal rats are not identical to adults, they also have the capability to efficiently metabolize BPA. As a result of efficient metabolism, estrogenic effects from BPA are unlikely due to the very low levels of unmetabolized BPA in the body after oral exposure. Because BPA is efficiently metabolized after oral exposure, studies that expose animals by subcutaneous injection are of limited relevance to human health concerns that primarily involve oral exposure. Because of efficient metabolism and rapid elimination, BPA does not accumulate in the body.