Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats

Author: Donald Stump
Publication: Toxicological Sciences
Date: January 22, 2010

The objective of this study, conducted in Sprague-Dawley rats, was to determine the potential of BPA to induce functional and/or morphological effects to the nervous system of offspring following dietary exposure of the mother during pregnancy and lactation. In this study, pregnant female rats were exposed to BPA via the diet at dosage levels that spanned the range from low doses, as used in some published studies reporting developmental neurotoxicity, to a high dose that was anticipated to result in systemic toxicity in the pregnant rat (0, 0.01, 0.1, 5, 50, and 150 mg/kg/day).

The offspring, exposed to BPA in utero, via milk while nursing and through the diet once they started to feed, were studied for functional or morphological effects on their nervous systems. The study concluded that there were no neurologic or neurobehavioral effects at any dose tested.